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Oxycodone is indicated for the treatment of moderate and severe pain, but the extended release formulation has been used in chronic, moderate to severe cases requiring continuous opioid analgesics for a long period. Buy Oxycodone Online
So Oxycodone is a semisynthetic opioid analgesic.
it was derived from thebaine in Germany in 1917 And is currently useful as an immediate release product for moderate and serious pain.
Because The first oxycodone containing product is Percodan and was approved by the FDA on April 12, 1950. so Buy Oxycodone Online
Mechanism of action of Oxycodone Online
The full mechanism of oxycodone is not known. But Under conditions of inflammation or hyperalgesia, opioid receptors in the heart, lungs, liver, gastrointestinal tract, and so reproductive system are upregulated and transported to nerve terminals.
Oxycodone and its active metabolites, nor oxycodone, oxymorphone, and noroxymorphone are opioid agonists.
These compounds passively diffuse across the blood brain barrier but may be actively transported across by an unknown mechanism. So Buy Oxycodone Online at Low Price
Oxycodone and its active metabolites, can selectively bind to the mu opioid receptor. and the kappa and delta opioid receptors in the central nervous system and periphery induce a G protein coupled receptor signaling pathway.
so Activation of mu opioid receptors inhibits N-type voltage operated calcium channels, inhibiting responses to pain.
Dosage and Administration of Oxycodone
Oxycodone 60 mg and 80 mg tablets, as a single dose greater than 40 mg, so a total daily dose greater than 80 mg are only for use in patients in whom tolerance to an opioid of comparable potency has been established. Buy Oxycodone Online at Low Price
- Patients who are considered opioid-tolerant, are those taking it for one week or longer. but at least 60 mg oral morphine per day, 25 mcg transdermal fentanyl per hour, 30 mg oral oxycodone per day, 8 mg oral hydromorphone per day, 25 mg oral oxymorphone per day, 60 mg oral hydrocodone per day, or an equal analgesic dose of another opioid.
- Use the lowest effective dosage, but for the shortest duration consistent with individual patient treatment goals.
- Individualize dosing based on the severity of pain, Patient response, prior analgesic experience, and risk factors for addiction, abuse, and misuse. Buy Oxycodone Online Prescription
- Instruct patients to swallow tablets intact and not to cut, break, chew, crush, or dissolve tablets (risk of potentially fatal dose).
- Instruct patients to take one tablets at a time, With enough water to ensure complete swallowing immediately after placing it in the mouth.
- So do not abruptly discontinue Oxycodone as in a physically dependent patient.
Adults: For opioid-naïve and opioid non-tolerant patients, initiate with 10 mg tablets orally every 12 hours.
Because Oxycodone has an oral bioavailability of 60% to 87% .
This is unaffected by food and maintenance of therapy.
Pediatric Patients 11 Years of Age and Older
- For use only in pediatric patients 11 years,
- And older receiving but tolerating opioids for at least 5 consecutive days with a minimum of 20 mg per day of oxycodone, but its equivalent for at least two days immediately preceding dosing with Oxycodone. Buy Oxycodone Online Prescription
Side Effects of Oxycodone
- Low blood pressure
- Increased prostate size or difficulty passing urine
- Chronic lung, liver and kidney disease
- Problems with recent surgery on your gall bladder or bile duct
- Inflammation of the pancreases
- Adrenal glands not working properly
- Underactive thyroid gland
- Inflammatory bowel disease or recent abdominal surgery
- Severe mental condition involving loosing contact with reality, hearing voices or an inability to think clearly
- An addiction or history of abuse of alcohol, opioids or other drugs. Also history of abuse of alcohol, opioids or other drugs.
Contraindications of Oxycodone
Oxycodone is contraindicated in patients with known hypersensitivity to oxycodone, and in any situation where opioids are contraindicated. Buy Oxycodone Online Prescription
-Significant respiratory depression.
-Acute or severe bronchial asthma in an unmonitored setting or in absence of resuscitative equipment.
-Known or suspected gastrointestinal obstruction, including paralytic ileus.
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